Clonal Selection

Lymphocyte clones
Anti-A Anti-B Anti-C
Anti-A B-Cell Anti-B B-Cell Anti-C B-Cell
 1° Ag contact Arrow Arrow
Ag Bound to B-Cell
Arrow Arrow Proliferation stage
Anti-A B-Cell Anti-A B-Cell
Arrow Arrow Arrow Arrow
Anti-A B-Cell Anti-A B-Cell Anti-A B-Cell Anti-A B-Cell
Arrow Arrow Arrow Arrow Differentiation stage
Plasma Cell Plasma Cell Plasma cells Anti-A Memory Cell Anti-A Memory Cell Memory cells
Arrow Arrow Arrow Arrow Arrow 2° Ag contact
Effector cells produce
anti-A antibody		 Ag Bound to B-Cell Ag Bound to B-Cell
Arrow Arrow Arrow Arrow
Anti-A B-Cell Anti-A B-Cell Anti-A B-Cell Anti-A B-Cell
ArrowArrow ArrowArrow ArrowArrow ArrowArrow
Plasma Cell   Plasma Cell Plasma Cell   Plasma Cell Plasma Cell   Plasma Cell Anti-A Memory Cell   Anti-A Memory Cell
Effector cells produce anti-A antibody Memory cells remain

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