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Publications and Abstracts

Richard L. Mitchell, Ph.D.
 

 

PUBLICATIONS

 

Herz, J.M., Thomsen, W.J., Mitchell, R., and Yarbrough, G.G. 1996. Receptors for Drugs. Encyclopedia of Pharmaceutical Technology, J. Swarbrick and J.C. Boylan eds. vol. 13, Marcel Dekker, Inc., New York.

 

Hill, P., Y. Lai, J. Hnilo, C-C. Lin, M. Karla, S. Bounds, D. Middlemas, J. Herz, R.L. Mitchell 1996. Cloning, expression, and comparison of the binding characteristics of the known human dopamine receptors. Advances in Neurology 69:41-52, Lippencott-Raven, Philadelphia.

 

Felder, C.C., Joyce, K.E., Briley, E.M., Mansouri, J., Mackie, K., Lai, Y., Mitchell, R.L., Ma, A.L. 1995. Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 Receptors. Mol. Pharm. 48(3):443-450.

 

Mackie, K., Y. Lai, R. Westenbroek, R. Mitchell.  1995.  Cannabinoids activate an inwardly rectifying potassium conductance and inhibit non-L,N,P,T type voltage-dependent calcium currents in AtT20 cells transfected with rat brain cannabinoid receptor.  J. Neuroscience 15(10):6552-6561.

 

Tischer, E., R. Mitchell, T. Hartman, M. Silva, D. Gospodarowicz, J. C. Fiddes and J. A. Abraham, 1991.  The human gene for vascular endothelial growth factor:  Multiple protein forms are encoded through alternative exon splicing.  J. Biol. Chem. 266:11947-11954.

 

Tischer, E., D. Gospodarowicz, R. L. Mitchell, M. Silva, J. Schilling, K. Lau, T. Crisp, J. C. Fiddes, and J. A. Abraham.  1989.  Vascular endothelial growth factor:  A new member of the platelet-derived growth factor gene family.  Biochem. Biophys. Res. Commun.  165:1198-1206.

 

Blam, S. B., R. Mitchell, E. Tischer, J. S. Rubin, M. Silva, S. Silver, J. C. Fiddes, J. Abraham, S. Aaronson.  1988.  Addition of growth hormone secretion signal to basic fibroblast growth factor results in cell transformation and secretion of aberrant forms of the protein.  Oncogene 3:129-136.

 

Neufeld, G., R. Mitchell, P. Ponte, and D. Gospodarowicz.  1988.  Expression of human basic fibroblast growth factor cDNA in baby hamster kidney-derived cells results in autonomous cell growth.  J. Cell. Biol.  106:1385-1394.

 

Ferrara, N., L. Schweigerer, G. Neufeld, R. Mitchell, and D. Gospodarowicz.  1987.  Pituitary follicular cells produce basic fibroblast growth factor.  Proc. Natl. Acad. Sci.  USA 84:5773-5777. (article)

 

Neufeld, G., N. Ferrara, L. Schweigerer, R. Mitchell, and D. Gospodarowicz.  1987.  Bovine granulosa cells produce basic fibroblast growth factor.  Endocrinology 121:597-603.

 

Mitchell, R. L., S. K. Hanks, and I. M. Verma.  1987.  "Protooncogene fos:  An inducible multifaceted gene".  In:  Symposium on fundamental cancer research, Vol. 39, pp99-113.  University of Texas System Cancer Center.

 

Billestrup, N., R. L. Mitchell, W. Vale, and I. M. Verma.  1987.  "Growth hormone releasing factor induces c-fos expression in cultured primary pituitary cells".  Molecular Endocrinology 1:  300-305.

 

Van Beveren, C., R. L. Mitchell, C. Henning-Chubb, E. Huberman, and I. M. Verma.  1987.  "Expression of the c-fos gene during differentiation".  Adv. Exp. Med. Biol. 213:263-274.

 

Mitchell R. L., C. Henning-Chubb, E. Huberman, and I. M. Verma.  1987. "c-fos expression is neither sufficient nor obligatory for differentiation of monomyelocytes to macrophages".  Cell 45:497-504.

 

Verma, I. M., R. L. Mitchell, P. Sassone-Corsi.  1986.  Proto-oncogene fos:  an inducible gene.  Princess Takamatsu Symposium 17:279-290.

 

Mitchell, R. L., W. Kruijer, D. Schubert, C. Van Beveren, and I. M. Verma.  1986.  "Structure and expression of protooncogene fos".  In:  Proceedings of the Seventh International Symposium on Host Defense Mechanisms Against Cancer.  Excerpta Medica, Tokyo.

 

Mitchell, R. L.  1986.  "Post development intensification of autoradiographs".  BRL Focus 8(3):10-11.

 

Coussens, L., C. Van Beveren, D. Smith, E. Chen, R. L. Mitchell, C. M. Isacke, I. M. Verma, and A. Ulrich, 1986.  "Molecular architecture of receptor proto-oncogene fms:  Structural alteration of viral homologue at carboxyl terminus".  Nature 320:  277-280.

 

Verma, I. M., R. L. Mitchell, W. Kruijer, C. Van Beveren, L. Zokas, T. Hunter, and J. A. Cooper.  1985.  "Protooncogene fos:  Induction and regulation during growth and differentiation.  Cancer Cells.  3:  Growth factors and transformation".  Feramisco, J., B. Ozanne, and C. Stiles, Eds.  Cold Spring Harbor Laboratory, New York.  pp 275-287.

 

Mitchell, R. L., L. Zokas, R. D. Schreiber, and I. M. Verma.  1985.  "Rapid induction of the expression of proto-oncogene fos during human monocyte differentiation".  Cell 40:  209-217.

 

Deschamps, J., R. L. Mitchell, F. Meijlink, W. Kruijer, D. Schubert, and I. M. Verma.  1985.  "Proto-oncogene fos is expressed during development, differentiation, and growth".  Cold Spring Harbor Symposia on Quantitative Biology 50:  733-745.

 

Krzyzek, R. A., R. L. Mitchell, A. F. Lau, and A. J. Faras.  1980.  "Association of pp60src and src protein kinase activity with the plasma membrane of nonpermissive and permissive avian sarcoma virus-infected cells".  J. Virol. 36805-815.

 

Crouch, N.A., and R. L. Mitchell.  1978.  "Replication of vesicular stomatitis virus is facilitated by Shope fibroma virus in vivo".  Infect. Imm. 25:  213-219.

 

 

ABSTRACTS

 

N. Lautermilch, A. Bishop, K. Marcoe, S. Bounds, C-H. Lin, J-J. Feng, A. Lin, F-C. Cheng, R. Mitchell, P. Chiu, J. Baumgartner. 2005.  Comparison of a hERG Binding Assay with Automated Patch Clamp Using the PatchXpress 7000A.  Soc. Biolmol. Screening Ann. Mtg.

 

Marcoe, K.F., Mitchell, R.L., Baumgartner, J.W.  Binding Affinity of Amyloidogenic, Inflammatory and Antimicrobial Immunogenic Peptide Ligands to the Formyl Peptide Receptor-Like 1.  2004. Soc Biomol. Screening Annual Mtg.

 

Mulligan, J. Castillo, G., Mitchell. R.L. 2003. Characterization of Cathepsin Substrate and Inhibitor Specificities. Soc. Biol. Screening Ann. Mtg.

 

Shen, E., Mulligan, J., Castillo, G., Mitchell, R. 2004. FastKinaseTM for Rapid Determination of Multiple IC50 Profiles in a Panel of 24 Kinases.  Soc. Biol. Screening Ann. Mtg.

 

S. Bounds, R. Mitchell.  2004. Development of High Throughput Matrix Metalloproteinase Activity Assays.  Soc. Biolmol. Screening Ann. Mtg.

 

P. Chiu, F-C. Cheng, A. Lin, K-K. Chang, R. Mitchell, N. Share, D. Menard. 2004.  An Integrated Approach to Screen for Anti-Diabetic Agents.  Soc. Biolmol. Screening Ann. Mtg.

 

Marcoe, K.F. and Mitchell, R.L..  2004.  A High Throughput Radioligand Binding Assay for the Leptin OB-Rb Receptor.  Soc. Biolmol. Screening Ann. Mtg.

 

Y. Lai, K. Mackie, R. Mitchell.  1994.  Cannabinoids activate an inwardly rectifying potassium conductance and inhibit a calcium current in AtT20 cells expressing rat cannabinoid receptor.  Can. J. Physiol. Pharmacol. 72 (Suppl. 1):423.

 

P. Hill, Y. Lai, J. Hnilo, D. S. Middlemas, C. Lin, H. Hsing, F. Leung, M. Karla, S. Bounds, J. Herz, C. Chen, R. Mitchell.  1994.  Comparison of binding characteristics of the known human dopamine receptors.  Can. J. Physiol. Pharmacol. 72 (Suppl. 1):383.

 

Mitchell, R.L., P. Hill, Y. Lai, J. Hnilo, C. Lin, H. Hsing, F. Leung, M. Karla, S. Bounds, D. Middlemas, J. Herz.  1994.  Cloning, expression, and comparison of the binding characteristics of the known human dopamine receptors.  11th International Symposium on Parkinson's Disease, Rome.

 

Mitchell, R.  1994.  Human U937 promonocytes express an alternatively spliced mRNA encoding a shortened isoform of cytosolic phospholipase A2FASEB J. 8(4):A217.

 

Middlemas, D. S., P. Hill, Y. Lai, J. Hnilo, C. Lin, H. Hsing, F. Leung, M. Karla, S. Bounds, J. Herz, C. Chen, and R. Mitchell.  1994.  Comparison of binding characteristics of the known human dopamine receptors.  FASEB J. 8(4):A106.

 

Lai, Y., K. Mackie, R. Mitchell.  1994.  Cannabinoids activate an inwardly rectifying potassium conductance in AtT20 cells expressing rat cannabinoid receptor.  FASEB J. 8(4):A381.

 

Hill, P. A., and R. L. Mitchell.  1994.  Characterization of phosphodiesterase activity from U937 cells.  FASEB J. 8(4):A217.

 

Bounds, S., P. Hill, and R. Mitchell.  1994.  Development of a glucocorticoid receptor transcription response element (GTRE) assay.  FASEB J. 8(5):A650.

 

Hnilo, J. M., R. L. Mitchell, P. A. Hill, M. S. Crawford.  1991.  Development of functional tyrosine kinase assays based on EGF and PDGF receptor cytoplasmic domains expressed in Sf9 insect cells.  The Pharmacologist 33:174.

 

Mitchell, R. L., J. M. Hnilo, L. Maechler, M. S. Crawford.  1991.  Development of functional tyrosine kinase assays based on EGF and PDGF receptor cytoplasmic domains expressed in Sf9 insect cells.  Sixth S.E. Asia/W. Pacific Regional Mtg. of Pharmacologists.

 

Hnilo, J. M., R. L. Mitchell, L. Maechler, M. S. Crawford.  1991.  Developement of a functional tyrosine kinase assay based on EGF receptor tyrosine kinase domain expressed in Sf9 insect cells.  Soc. Indus. Microbiol.  Ann. Mtg., 1991. 

 

Mitchell, R. L., S. Silver, J. A. Abraham, J. C. Fiddes.  1988.  CHO cells transfected with basic fibroblast growth factor linked to growth hormone secretion signal efficiently secrete 18 kD FGF and several modified forms of the protein.  NCI-FCRF Fourth Ann. Mtg. On Oncogenes p429.

 

Blam, S. B., Mitchell, R., Tischer, E., Rubin, J. S., Silva, M., Silver, S., Fiddes, J. C., Abraham, J. A., Aaronson, S. A. 1988.  Addition of growth hormone secretion signal to basic fibroblast growth factor results in cell transformation and secretion of aberrant forms of the protein.  NCI-FCRF Fourth Ann. Mtg. on Oncogenes p24.

 

Mitchell, R. L., C. Henning-Chubb, E. Huberman, and I. M. Verma.  1987.  c-fos expression is neither sufficient nor obligatory for differentiation of monomyelocytes to macrophages.  In:  1987 Year Book of Cancer, Year Book Medical Publishers, Houston.

 

Mitchell, R. L., S. K. Hanks, C. Henning-Chubb, E. Huberman, and I. M. Verma.  1986.  Role of the protooncogene fos during growth and differentiation.  NCI-FCRF Second Ann. Mtg. On Oncogenes.

 

Mitchell, R. L., and I. M. Verma.  1985.  Expression of the protooncogenes c-fos and c-fms during hematopoietic differentiation.  NCI-FCRF First Annual Mtg. On Oncogenes.

 

Lau, A., A. Faras, R. Mitchell, and C. Collins.  1981.  ASV transformed and revertant field vole cells:  pp60src, cellular protein substrates, and arrangement of the integrated ASV genome.  1991 Ann. Mtg. on RNA Tumor Viruses.  Cold Spring Harbor Laboratories.

 

Crouch, N. A., and R. L. Mitchell.  1978.  Facilitative effect of Shope fibroma virus on the replication of vescicular stomatitis virus in vivo.  Abs. of the 78th Ann. Mtg. of the Am. Soc. Microbiol.

 

 

Richard L. Mitchell, Ph.D.
Discovery & Development Consulting, Technology Assessment
15920 177th Ave. NE
Woodinville, WA 98072 USA
+425.402.6341
+425.922.1393 (cell)
mitchellscience@verizon.net (principal e-mail)
richard@touchinglightphotography.com (alt. e-mail)